Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents.

ABSTRACT: Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists. Exploration of indole derivatives in drug discovery has rapidly yielded a vast array of biologically active compounds with broad therapeutic potential. Nature is the major source of indole scaffolds, but various classical and advanced synthesis methods for indoles have also been reported. One-pot synthesis is widely considered an efficient approach in synthetic organic chemistry and has been used to synthesize some indole compounds. The rapid emergence of drug-resistant tuberculosis is a major challenge to be addressed. Identifying novel targets and drug ca

SUBMITTER: Bajad NG 

PROVIDER: S-EPMC9389259 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature