Baseline lymphocyte and cholinesterase levels may be the predictors of chronic herbal drug-induced liver injury.

ABSTRACT: Objective: To investigate the factors influencing the chronicity of drug-induced liver injury (DILI) caused by Chinese herbal medicine. Methods: Patients with DILI diagnosed by using the RUCAM score were enrolled retrospectively. The subjects were patients with DILI induced by taking Chinese herbal medicine and were followed up for 48 weeks. These patients were divided into a cure group and a chronic group. The biochemical indicators were monitored at baseline and every 3 months. Logistic regression was used to analyze the risk factors of DILI chronicity. The ROC (receiver operator characteristic) curve was used to analyze the diagnostic efficiency of each factor. Results: A total of 420 patients with DILI were enrolled; 122 of them were caused by Chinese herbal medici

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC9389325 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature