Participation of Lower and Upper Middle-Income Countries in Clinical Trials Led by High-Income Countries.

ABSTRACT:

Importance

Many randomized clinical trials (RCTs) led by high-income countries (HICs) now enroll patients from lower middle-income countries (LMICs) and upper middle-income countries (UMICs). Although enrolling diverse populations promotes research collaborations, there are issues regarding which countries participate in RCTs and how this participation may contribute to global research.

Objective

To describe which UMICs and LMICs participate in RCTs led by HICs.

Design, setting, and participants

A cross-sectional study of all oncology RCTs published globally during January 1, 2014, to December 31, 2017, was conducted. The study cohort was restricted to RCTs led by HICs that enrolled participants from LMICs and UMICs. Study analyses were conducted in November 1, 2021,

SUBMITTER: Rubagumya F 

PROVIDER: S-EPMC9389348 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature