The potential effects and mechanisms of breast inflammatory lesions on the occurrence and development of breast cancer.

ABSTRACT: Breast cancer as the most common cancer in women has become the leading cause of cancer death for women. Although many inflammatory factors increase the risk of breast cancer, there are very few studies on the mechanisms by which inflammation affects the initiation and progression of breast cancer. Here, we profiled and compared the transcriptome of normal tissues, inflammatory breast tissues, benign breast tumors, and malignant breast tumors. To find key regulatory factors, a protein interaction network between characteristic modules in inflammatory lesions and ER-negative (ER^-) breast cancer was constructed and inflammation-cancer interface genes were identified. We found that the transcriptional profile of inflammatory breast tissues was similar with ER^- malignant

SUBMITTER: Chang Z 

PROVIDER: S-EPMC9389363 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature