Immune globulin therapy and kidney disease: Overview and screening, monitoring, and management recommendations.

ABSTRACT:

Purpose

This report calls attention to the potential risks of diminished kidney function when administering immune globulin (IG). The goal is to increase awareness of chronic kidney disease (CKD) and kidney function impairment in patients receiving IG and provide recommendations for screening, monitoring, and management to promote risk prevention and mitigation.

Summary

Human IG preparations for intravenous (IVIG) or subcutaneous (SCIG) administration are the mainstay of treatment in patients with primary immunodeficiency diseases. Increasingly, IVIG at high doses (1,000 to 2,400 mg/kg) is also used as a treatment for a variety of autoimmune and inflammatory conditions. Although some autoinflammatory disorders respond to a single course of IVIG therapy, the majority of patie

SUBMITTER: Kobayashi RH 

PROVIDER: S-EPMC9389421 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature