Acute lyme disease IgG N-linked glycans contrast the canonical inflammatory signature.
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ABSTRACT:
SUBMITTER: Haslund-Gourley BS
PROVIDER: S-EPMC9389449 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Acute lyme disease IgG N-linked glycans contrast the canonical inflammatory signature.
Haslund-Gourley Benjamin Samuel BS Grauzam Stéphane S Mehta Anand S AS Wigdahl Brian B Comunale Mary Ann MA
Frontiers in immunology 20220805
Lyme disease (LD) infection is caused by <i>Borrelia burgdorferi</i> sensu <i>lato</i> (Bb). Due to the limited presence of this pathogen in the bloodstream in humans, diagnosis of LD relies on seroconversion. Immunoglobulins produced in response to infection are differentially glycosylated to promote or inhibit downstream inflammatory responses by the immune system. Immunoglobulin G (IgG) N-glycan responses to LD have not been characterized. In this study, we analyzed IgG N-glycans from cohorts ...[more]
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