Immunomodulatory Bandage for Accelerated Healing of Diabetic Wounds.

ABSTRACT: Diabetic foot ulcers are challenging to treat. Current strategies to treat these wounds focus on preventing infection and promoting tissue regrowth but are ineffective in many individuals. Low-grade chronic inflammation is present in individuals with diabetes, and altering the inflammatory responses at the wound site could be an alternate approach to promote healing. We hypothesized that immunomodulation of the wound microenvironment would result in accelerated healing. To test this hypothesis, we began by characterizing the changes in the myeloid cell phenotype in a mouse model [leptin receptor knockout (KO) mouse] that closely mimics the type 2 diabetes condition observed in humans. We observed increased numbers of monocytes and neutrophils in the circulation of the KO mice compared to t

SUBMITTER: Raghavan JV 

PROVIDER: S-EPMC9389529 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature