Tandem Mass Spectrometry as an Independent Method for Corroborating Fluorine-18 Radioactivity Measurements in Positron Emission Tomography.

ABSTRACT: Positron emission tomography (PET) uses many tracers labeled with fluorine-18 (t _1/2 = 109.8 min; β⁺ 97%) for quantitative imaging of biochemical and physiological processes in animal and human subjects. In PET methodology, the radioactivity in a dose of an ¹⁸F-labeled tracer to be administered to a living subject is measured with a calibrated ionization chamber. This type of detector measures the radioactivity of a sample relative to those of certified amounts of longer-lived surrogate isotopes that are recommended for detector calibration. No alternative means for corroborating widely varying fluorine-18 radioactivity measurements from calibrated ionization chambers has been available. Here, we describe an independent nonradiometric method for this

SUBMITTER: Shetty HU 

PROVIDER: S-EPMC9389646 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature