Melatonin inhibits NaIO₃-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling.

ABSTRACT:

Background

Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the role it plays in AMD remains unclear. Herein, we investigated the anti-AMD molecular mechanism of melatonin after sodium iodate (NaIO3) treatment of ARPE-19 cells in vitro and in animal models with the goal of improving the therapeutic effect.

Results

The in vitro results showed that melatonin protected against NaIO₃-induced cell viability decline, mitochondrial dysfunction and apoptosis in ARPE-19 cells, and melatonin also alleviated NaIO₃-induced reactive oxygen species (ROS) production, mitochondrial dysfunction and mitophagy activat

SUBMITTER: Wang K 

PROVIDER: S-EPMC9389659 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature