Goal-directed therapy based on rScO₂ monitoring in elderly patients with one-lung ventilation: a randomized trial on perioperative inflammation and postoperative delirium.

ABSTRACT:

Background

The incidence of postoperative delirium (POD) is high in elderly patients with one-lung ventilation, which is mostly related to the impairment of cerebral oxygen supply/demand balance during operation. (Surgical) stress can cause changes to normal physiological function and increase oxygen supply to the brain. When cerebral oxygen supply/demand is unbalanced, other organs may have already suffered from hypoperfusion or even hypoxic damages leading to increased release of inflammatory factors. Regional saturation of cerebral oxygenation (rScO₂) monitoring can noninvasively monitor the variation of regional cerebral oxygen supply/demand balance in real time, and it has a good correlation with the occurrence of POD. S-100β is one of the markers commonly used to p

SUBMITTER: Wang JY 

PROVIDER: S-EPMC9389685 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature