Colorectal cancer risk in association with colorectal cancer as a second malignancy in relatives: a nationwide cohort study.

ABSTRACT:

Background

Increasing number of individuals will have first-degree relatives (FDRs) diagnosed with colorectal cancer (CRC), as a second primary malignancy (CRCa-2) after a non-CRC cancer. We aimed to estimate whether and to what extent a family history of CRCa-2 is associated with an increased CRC risk.

Methods

In this Swedish nationwide cohort study, rate ratio (RR) and cumulative incidence of CRC were estimated among 172,531 individuals with a family history of CRC as a first primary malignancy (CRCa-1) and 17,830 with a family history of CRCa-2, respectively, using individuals without cancer family history as the reference group.

Results

A cumulative incidence of CRC by age 80 was 6.3 and 5.6% for individuals with a parental and a sibling family history of CRCa-2,

SUBMITTER: Zheng G 

PROVIDER: S-EPMC9389686 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature