Synthesis and Biological Activity of Highly Cationic Dendrimer Antibiotics.

ABSTRACT: The development of pathogenic bacteria resistant to current treatments is a major issue facing the world today. Here, the synthesis and biological activity of fourth generation poly(amidoamine) dendrimers decorated with 1-hexadecyl-azoniabicylo[2.2.2]octane (C₁₆-DABCO), a quaternary ammonium compound known to have antibacterial activity, are described. This highly cationic dendrimer antibiotic was tested against several Gram positive and Gram negative strains of pathogenic bacteria and exhibited activity against both. Higher activity toward the Gram positive strains that were tested was observed. After the antimicrobial activity was assessed, E. coli and B. cereus were subjected to a resistance selection study. This study demonstrated that a multivalent approach to antimicrobial

SUBMITTER: VanKoten HW 

PROVIDER: S-EPMC9389851 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature