Stereoselective β-Mannosylation via Anomeric O-Alkylation with L-Sugar-Derived Electrophiles.

ABSTRACT: A total synthesis of the trisaccharide repeat unit of Salmonella serogroup E1 O-antigen is reported. This synthesis features a key β-mannosylation reaction via cesium carbonate-mediated anomeric O-alkylation of a partially protected D-mannose with an L-fucose-derived electrophile for the first time.

SUBMITTER: Hettiarachchi IL 

PROVIDER: S-EPMC9389860 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature