Determinants and Temporal Dynamics of Cerebral Small Vessel Disease: 14-Year Follow-Up.

ABSTRACT:

Background

The aim of this study is to investigate the temporal dynamics of small vessel disease (SVD) and the effect of vascular risk factors and baseline SVD burden on progression of SVD with 4 neuroimaging assessments over 14 years in patients with SVD.

Methods

Five hundred three patients with sporadic SVD (50-85 years) from the ongoing prospective cohort study (RUN DMC [Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort]) underwent baseline assessment in 2006 and follow-up in 2011, 2015, and 2020. Vascular risk factors and magnetic resonance imaging markers of SVD were evaluated. Linear mixed-effects model and negative binomial regression model were used to examine the determinants of temporal dynamics of SVD markers.

Results

A total of 382

SUBMITTER: Cai M 

PROVIDER: S-EPMC9389939 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature