Genomic crossroads between non-Hodgkin's lymphoma and common variable immunodeficiency.

ABSTRACT: Common variable immunodeficiency (CVID) represents the largest group of primary immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and cancer, mainly B-cell non-Hodgkin's lymphoma (NHL). Indeed, NHL may result from chronic or recurrent infections and has, therefore, been recognized as a clinical phenotype of CVID, although rare. The more one delves into the mechanisms involved in CVID and cancer, the stronger the idea that both pathologies can be a reflection of the same primer events observed from different angles. The potential effects of germline variants on specific somatic modifications in malignancies suggest that it might be possible to anticipate critical events during tumor development. In the same way, a somatic alteration in NHL could be conditioni

SUBMITTER: Guevara-Hoyer K 

PROVIDER: S-EPMC9390007 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature