Mice with humanized immune system as novel models to study HIV-associated pulmonary hypertension.

ABSTRACT: People living with HIV and who receive antiretroviral therapy have a significantly improved lifespan, compared to the early days without therapy. Unfortunately, persisting viral replication in the lungs sustains chronic inflammation, which may cause pulmonary vascular dysfunction and ultimate life-threatening Pulmonary Hypertension (PH). The mechanisms involved in the progression of HIV and PH remain unclear. The study of HIV-PH is limited due to the lack of tractable animal models that recapitulate infection and pathobiological aspects of PH. On one hand, mice with humanized immune systems (hu-mice) are highly relevant to HIV research but their suitability for HIV-PH research deserves investigation. On another hand, the Hypoxia-Sugen is a well-established model for experimental PH that co

SUBMITTER: Rodriguez-Irizarry VJ 

PROVIDER: S-EPMC9390008 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature