Quantification of local zinc and tungsten deposits in bone with LA-ICP-MS using novel hydroxyapatite-collagen calibration standards.

ABSTRACT: Tungsten has recently emerged as a potential toxicant and is known to heterogeneously deposit in bone as reactive polytungstates. Zinc, which accumulates in regions of bone remodeling, also has a heterogenous distribution in bone. Determining the local concentrations of these metals will provide valuable information about their mechanisms of uptake and action. A series of bone (BN), 7:3 hydroxyapatite:collagen (HC), and hydroxyapatite (HA) standards were spiked with tungsten and zinc and used as calibration standards for laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analysis of bone tissue. The analytical performance of these standards was studied and validated at different step sizes using NIST SRM 1486 Bone Meal. The effect of matrix-matched calibration was asse

SUBMITTER: VanderSchee CR 

PROVIDER: S-EPMC9390078 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature