A pilot study of ⁶⁸ Ga-PSMA-617 PET/CT imaging and ¹⁷⁷Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma.

ABSTRACT:

Background

This pilot study was designed to evaluate the diagnostic value of ⁶⁸ Ga-PSMA-617 and ¹⁸F-FDG PET/CT in adenoid cystic carcinoma (ACC) and to assess the safety and therapeutic response to PSMA radioligand therapy (RLT) in ACC patients.

Methods

Thirty patients pathologically diagnosed with ACC were recruited into the cohort. Each patient underwent ⁶⁸ Ga-PSMA-617 and ¹⁸F-FDG PET/CT within 1 week. The number and SUVmax of PET-positive lesions were recorded and compared. Four patients accepted RLT using ¹⁷⁷Lu-EB-PSMA-617, in a dosage of approximately 1.85 GBq (50 mCi) per cycle for up to 3 cycles.

Results

Compared with ¹⁸F-FDG, ⁶⁸ Ga-PSMA-617 revealed more PET-positive extrapulmonary tu

SUBMITTER: Wang G 

PROVIDER: S-EPMC9390098 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature