Early gut microbiota in very low and extremely low birth weight preterm infants with feeding intolerance: a prospective case-control study.

ABSTRACT: The potential role of the gut microbiota in the pathogenesis of feeding intolerance (FI) remains unclear. Understanding the role of the gut microbiota could provide a new avenue for microbiota-targeted therapeutics. This study aimed to explore the associations between aberrant gut microbiota and FI in very low or extremely low birth weight (VLBW/ELBW) preterm infants. In this observational case-control study, VLBW/ELBW infants were divided into two groups: FI group and feeding tolerance (FT) group. 16S rRNA gene sequencing was performed to analyze the gut microbial diversity and composition of the infants. The differences in the gut microbiota of the two groups were compared. In total, 165 stool samples were obtained from 44 infants, among which, 31 developed FI and 13 served as controls.

SUBMITTER: Liu L 

PROVIDER: S-EPMC9390111 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature