Cardio-omentopexy requires a cardioprotective innate immune response to promote myocardial angiogenesis in mice.

ABSTRACT:

Objective

The pedicled greater omentum, when applied onto stressed hearts using omentopexy, has been shown to be protective in humans and animals. The mechanisms underlying cardioprotection using omentopexy remain elusive. This study examined whether macrophage-mediated angiogenesis accounts for the cardioprotective effect of omentopexy in mice.

Methods

C57BL/6 mice were subjected to minimally invasive transverse aortic constriction for 6 weeks and subsequent cardio-omentopexy for 8 weeks. Control mice underwent the same surgical procedures without aortic constriction or cardio-omentopexy.

Results

Transverse aortic constriction led to left ventricular concentric hypertrophy, reduced mitral E/A ratio, increased cardiomyocyte size, and myocardial fibrosis in the mice th

SUBMITTER: Ge ZD 

PROVIDER: S-EPMC9390370 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature