Aortic valve replacement in sheep with a novel trileaflet mechanical heart valve prosthesis without anticoagulation.

ABSTRACT:

Background

Even after decades of intensive research, an ideal heart valve prosthesis remains elusive. Shortcomings of conventional devices include reduced durability of bioprostheses and the thrombogenicity of mechanical substitutes, necessitating anticoagulation and resulting in imperfect hemodynamics. Here we present in vivo results of a novel mechanical heart valve prosthesis aiming for freedom from anticoagulation.

Methods

Four female sheep had their aortic valves replaced using the novel mechanical heart valve (size 21 mm), with no postoperative anticoagulation treatment. This trileaflet heart valve was designed with the pivots in the systolic central flow. Hemodynamics, biochemistry, hematology, and macroscopy and microscopy were studied at 90 days in 2 sheep and at 1 

SUBMITTER: Schaller T 

PROVIDER: S-EPMC9390555 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature