Improving outcomes for transplantation in failing Fontan-what is the next target?

ABSTRACT:

Objective

To identify the key contributors to postoperative mortality in patients undergoing orthotopic heart transplantation (OHT) for late Fontan failure.

Methods

This retrospective review of failing Fontan patients who underwent OHT in our tertiary care center between 2007 and 2019 included adult patients with congenital heart disease and single ventricle physiology who were palliated with a Fontan circulation for >1 year. We excluded patients undergoing combined heart-liver transplantation.

Results

The study cohort comprised 31 patients, including 18 males (58.1%), with a mean weight of 58.4 kg, median age at Fontan of 6.9 years (interquartile range [IQR], 2-38 years), and a median age at OHT of 27.1 years (IQR, 16.7-53.3). Almost all (93.5%) of the patients were

SUBMITTER: Cardoso B 

PROVIDER: S-EPMC9390714 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature