BRAF-Mutated Advanced Colorectal Cancer: A Rapidly Changing Therapeutic Landscape.

ABSTRACT: BRAF-mutated advanced colorectal cancer is a relatively small but critical subset of this tumor type on the basis of prognostic and predictive implications. BRAF alterations in colorectal cancer are classified into three functional categories on the basis of signaling mechanisms, with the class I BRAF^V600E mutation occurring most frequently in colorectal cancer. Functional categorization of BRAF mutations in colorectal cancer demonstrates distinct mitogen-activated protein kinase pathway signaling. On the basis of recent clinical trials, current standard-of-care therapies for patients with BRAF^V600E-mutated metastatic colorectal cancer include first-line cytotoxic chemotherapy plus bevacizumab and subsequent ther

SUBMITTER: Ciombor KK 

PROVIDER: S-EPMC9390817 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature