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Immunologic Strategies in Pancreatic Cancer: Making Cold Tumors Hot.

ABSTRACT: The rising incidence and persistent dismal 5-year overall survival of pancreatic ductal adenocarcinoma (PDAC) highlight the need for new effective systemic therapies. Immunotherapy has shown significant benefits in solid organ tumors, but has thus far been disappointing in the treatment of PDAC. There have been several promising preclinical studies, but translation into the clinic has proved to be challenging. This is likely a result of PDAC's complex immunosuppressive tumor microenvironment that acts to insulate the tumor against an effective cytotoxic immune response. Here, we summarize the mechanisms of immunosuppression within the PDAC tumor microenvironment and provide an up-to-date review of completed and ongoing clinical trials using various immunotherapy strategies.

SUBMITTER: Ullman NA

PROVIDER: S-EPMC9390820 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Immunologic Strategies in Pancreatic Cancer: Making <i>Cold</i> Tumors <i>Hot</i>.

Ullman Nicholas A NA Burchard Paul R PR Dunne Richard F RF Linehan David C DC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20220715 24

The rising incidence and persistent dismal 5-year overall survival of pancreatic ductal adenocarcinoma (PDAC) highlight the need for new effective systemic therapies. Immunotherapy has shown significant benefits in solid organ tumors, but has thus far been disappointing in the treatment of PDAC. There have been several promising preclinical studies, but translation into the clinic has proved to be challenging. This is likely a result of PDAC's complex immunosuppressive tumor microenvironment tha ...[more]

PMID: 35839445

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