Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum.

ABSTRACT: Despite ongoing efforts to control malaria infection, progress in lowering the number of deaths and infections appears to have stalled. The continued high incidence of malaria infection and mortality is in part due to emergence of parasites resistant to frontline antimalarials. This highlights the need for continued identification of novel protein drug targets. Mitochondrial functions in Plasmodium falciparum, the deadliest species of human malaria parasite, are targets of validated antimalarials including atovaquone and proguanil (Malarone). Thus, there has been great interest in identifying other essential mitochondrial proteins as candidates for novel drug targets. Garnering an increased understanding of the proteomic landscape inside the P. falciparum mitochondrion will also allow us t

SUBMITTER: Lamb IM 

PROVIDER: S-EPMC9390924 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature