Precision oncology for intrahepatic cholangiocarcinoma in clinical practice.

ABSTRACT:

Background

Advanced cholangiocarcinoma has a poor prognosis. Molecular targeted approaches have been proposed for patients after progression under first-line chemotherapy treatment. Here, molecular profiling of intrahepatic cholangiocarcinoma in combination with a comprehensive umbrella concept was applied in a real-world setting.

Methods

In total, 101 patients received molecular profiling and matched treatment based on interdisciplinary tumour board decisions in a tertiary care setting. Parallel DNA and RNA sequencing of formalin-fixed paraffin-embedded tumour tissue was performed using large panels.

Results

Genetic alterations were detected in 77% of patients and included gene fusions in 21 patients. The latter recurrently involved the FGFR2 and the NRG1 gene loci.

SUBMITTER: Tomczak A 

PROVIDER: S-EPMC9390961 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature