Predicting the potential for zoonotic transmission and host associations for novel viruses.

ABSTRACT: Host-virus associations have co-evolved under ecological and evolutionary selection pressures that shape cross-species transmission and spillover to humans. Observed virus-host associations provide relevant context for newly discovered wildlife viruses to assess knowledge gaps in host-range and estimate pathways for potential human infection. Using models to predict virus-host networks, we predicted the likelihood of humans as hosts for 513 newly discovered viruses detected by large-scale wildlife surveillance at high-risk animal-human interfaces in Africa, Asia, and Latin America. Predictions indicated that novel coronaviruses are likely to infect a greater number of host species than viruses from other families. Our models further characterize novel viruses through prioritization scores

SUBMITTER: Pandit PS 

PROVIDER: S-EPMC9390964 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature