Double-edged role of resource competition in gene expression noise and control.

ABSTRACT: Despite extensive investigation demonstrating that resource competition can significantly alter the deterministic behaviors of synthetic gene circuits, it remains unclear how resource competition contributes to the gene expression noise and how this noise can be controlled. Utilizing a two-gene circuit as a prototypical system, we uncover a surprising double-edged role of resource competition in gene expression noise: competition decreases noise through introducing a resource constraint but generates its own type of noise which we name as "resource competitive noise." Utilization of orthogonal resources enables retainment of the noise reduction conferred by resource constraint while removing the added resource competitive noise. The noise reduction effects are studied using three negative

SUBMITTER: Goetz H 

PROVIDER: S-EPMC9390979 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature