Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T₃) supplementation.

ABSTRACT: Diurnal (i.e., 24 hr) physiological rhythms depend on transcriptional programs controlled by a set of circadian clock genes/proteins. Systemic factors like humoral and neuronal signals, oscillations in body temperature, and food intake align physiological circadian rhythms with external time. Thyroid hormones (THs) are major regulators of circadian clock target processes such as energy metabolism, but little is known about how fluctuations in TH levels affect the circadian coordination of tissue physiology. In this study, a high triiodothyronine (T₃) state was induced in mice by supplementing T₃ in the drinking water, which affected body temperature, and oxygen consumption in a time-of-day-dependent manner. A 24-hr transcriptome profiling of liver tissue identified 37

SUBMITTER: de Assis LVM 

PROVIDER: S-EPMC9391036 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature