Long-term microglial phase-specific dynamics during single vessel occlusion and recanalization.

ABSTRACT: Vascular occlusion leading to brain dysfunctions is usually considered evoking microglia-induced inflammation response. However, it remains unclear how microglia interact with blood vessels in the development of vascular occlusion-related brain disorders. Here, we illuminate long-term spatiotemporal dynamics of microglia during single vessel occlusion and recanalization. Microglia display remarkable response characteristics in different phases, including acute reaction, rapid diffusion, transition and chronic effect. Fibrinogen-induced microglial cluster promotes major histocompatibility complex II (MHCII) expression. Microglial soma represents a unique filament-shape migration and has slower motility compared to the immediate reaction of processes to occlusion. We capture proliferative mi

SUBMITTER: Xie X 

PROVIDER: S-EPMC9391347 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature