METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m⁶A-YTHDF2-dependent manner.

ABSTRACT: Uncontrolled epithelial cell proliferation in the prostate transition zone and the hyper-accumulation of mesenchymal-like cells derived from the epithelial-mesenchymal transition (EMT) of prostatic epithelium are two key processes in benign prostatic hyperplasia (BPH). m⁶A RNA modification affects multiple cellular processes, including cell proliferation, apoptosis, and differentiation. In this study, the aberrant up-regulation of methylase METTL3 in BPH samples suggests its potential role in BPH development. Elevated m⁶A modification in the prostate of the BPH rat was partially reduced by METTL3 knockdown. METTL3 knockdown also partially reduced the prostatic epithelial thickness and prostate weight, significantly improved the histological features of the prostate, i

SUBMITTER: Li J 

PROVIDER: S-EPMC9391461 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature