Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery.

ABSTRACT: Multiple studies have examined the transduction characteristics of different AAV serotypes in the mouse brain, where they can exhibit significantly different patterns of transduction. The pattern of transduction also varies with the route of administration. Much less information exists for the transduction characteristics in large-brained animals. Large animal models have brains that are closer in size and organization to the human brain, such as being gyrencephalic compared to the lissencephalic rodent brains, pathway organization, and certain electrophysiologic properties. Large animal models are used as translational intermediates to develop gene therapies to treat human diseases. Various AAV serotypes and routes of delivery have been used to study the correction of pathology in the bra

SUBMITTER: Hunter JE 

PROVIDER: S-EPMC9391516 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature