Positron range in combination with point-spread-function correction: an evaluation of different implementations for [124I]-PET imaging.

ABSTRACT:

Aim

To evaluate the effect of combining positron range correction (PRC) with point-spread-function (PSF) correction and to compare different methods of implementation into iterative image reconstruction for ¹²⁴I-PET imaging.

Materials and methods

Uniform PR blurring kernels of ¹²⁴I were generated using the GATE (GEANT4) framework in various material environments (lung, water, and bone) and matched to a 3D matrix. The kernels size was set to 11 × 11 × 11 based on the maximum PR in water and the voxel size of the PET system. PET image reconstruction was performed using the standard OSEM algorithm, OSEM with PRC implemented before the forward projection (OSEM+PRC simplified) and OSEM with PRC implemented in both forward- and back-projection steps (full imp

SUBMITTER: Kertesz H 

PROVIDER: S-EPMC9391565 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature