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NMDA receptor-targeted enrichment of CaMKIIα improves fear memory.

ABSTRACT: The establishment of effective molecular interventions to improve memory and alleviate memory deficits in disease remains a long-standing challenge despite growing molecular understanding of synaptic plasticity and memory formation. Capitalizing on the fact that long-term potentiation (LTP) requires N-methyl-D-aspartate receptors (NMDARs) and Ca²⁺/calmodulin-dependent protein kinase II alpha (CaMKIIα), we develop an intrabody that targets NMDARs and show that intrabody-mediated postsynaptic enrichment of CaMKIIα in the hippocampus improves contextual fear memory. This molecular approach suggests a potential demand for effective targeting of postsynaptic molecules to enhance memory and provides insights into studying memory improvement in health and disease.

SUBMITTER: Chifor A

PROVIDER: S-EPMC9391594 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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NMDA receptor-targeted enrichment of CaMKIIα improves fear memory.

Chifor Anthony A Choi Jeongyoon J Park Joongkyu J

iScience 20220802 8

The establishment of effective molecular interventions to improve memory and alleviate memory deficits in disease remains a long-standing challenge despite growing molecular understanding of synaptic plasticity and memory formation. Capitalizing on the fact that long-term potentiation (LTP) requires N-methyl-D-aspartate receptors (NMDARs) and Ca<sup>2+</sup>/calmodulin-dependent protein kinase II alpha (CaMKIIα), we develop an intrabody that targets NMDARs and show that intrabody-mediated postsy ...[more]

PMID: 35996578

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