Krebs von den Lungen 6 (KL-6) levels in COVID-19 ICU patients are associated with mortality.

ABSTRACT:

Background

Krebs von den Lungen 6 (KL-6) is a high-molecular-weight mucin-like glycoprotein, which is also known as MUC1. KL-6 is mainly produced by type 2 pneumocytes and bronchial epithelial cells, and, therefore, elevated circulating KL-6 levels may denote disorders of the alveolar epithelial lining. The objective of this study is to verify if KL-6 serum level might support ICU physicians in predicting mortality, risk stratifying and triaging severe COVID-19 patients.

Methods

A retrospective cohort study, including all the COVID-19 patients who measured KL-6 serum values at least once during their ICU stay, was performed. The study sample, 122 patients, was divided in two groups, according to the median KL-6 value at ICU admission (median log-transformed KL-6 value: 6.73

SUBMITTER: Scarpati G 

PROVIDER: S-EPMC9391655 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature