[Profile of malignant hyperthermia susceptibility reports confirmed with muscular contracture test in Brazil].

ABSTRACT:

Background and objectives

Malignant hyperthermia is an autosomal dominant hypermetabolic pharmacogenetic syndrome, with a mortality rate of 10%-20%, which is triggered by the use of halogenated inhaled anesthetics or muscle relaxant 10%-20% succinylcholine. The gold standard for suspected susceptibility to malignant hyperthermia is the in vitro muscle contracture test in response to halothane and caffeine. The determination of susceptibility in suspected families allows the planning of safe anesthesia without triggering agents for patients with known susceptibility to malignant hyperthermia by positive in vitro muscle contracture test. Moreover, the patient whose suspicion of malignant hyperthermia was excluded by the in vitro negative muscle contracture test may undergo standard a

SUBMITTER: Almeida da Silva HC 

PROVIDER: S-EPMC9391845 | biostudies-literature | 2019 Mar - Apr

REPOSITORIES: biostudies-literature