Disruption of Growth Hormone Receptor Signaling Abrogates Hepatocellular Carcinoma Development.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancers. It is an aggressive neoplasm with dismal outcome because most of the patients present with an advanced-stage disease, which precludes curative surgical options. Therefore, these patients require systemic therapies that typically induce small improvements in overall survival. Hence, it is crucial to identify new and promising therapeutic targets for HCC to improve the current outcome. The liver is a key organ in the signaling cascade triggered by the growth hormone receptor (GHR). Previous studies have shown that GHR signaling stimulates the proliferation and regeneration of liver cells and tissues; however, a definitive role of GHR signaling in HCC pathogenesis has not been identified.

SUBMITTER: Haque A 

PROVIDER: S-EPMC9391993 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature