Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients.

ABSTRACT: Neuroinflammation is recognized as a key component of neurodegenerative disease. In glaucoma, a common neurodegenerative disease and the leading cause of irreversible blindness, the evidence for neuroinflammation in patients is lacking. Animal models have demonstrated significant pro-inflammatory activation of resident glia in the retina, as well as influx of blood-derived monocytes and pro-inflammatory factors. Confirmation of this in human donor tissue has been challenging due to a lack of well-preserved and well-characterized post-mortem tissue. To address this we utilize archived, wax embedded eyes fixed immediately following enucleation from living glaucoma patients. We compared glaucoma to control eyes (enucleated for uveal melanoma where the tumor did not impact the central retina o

SUBMITTER: Rutigliani C 

PROVIDER: S-EPMC9392254 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature