Immune recognition of syngeneic, allogeneic and xenogeneic stromal cell transplants in healthy retinas.

ABSTRACT:

Background

Advanced therapies using adult mesenchymal stromal cells (MSCs) for neurodegenerative diseases are not effectively translated into the clinic. The cross talk between the transplanted cells and the host tissue is something that, despite its importance, is not being systematically investigated.

Methods

We have compared the response of the mouse healthy retina to the intravitreal transplantation of MSCs derived from the bone marrow in four modalities: syngeneic, allogeneic, xenogeneic and allogeneic with immunosuppression using functional analysis in vivo and histology, cytometry and protein measurement post-mortem. Data were considered significant (p < 0.05) after nonparametric suitable statistical tests.

Results

Transplanted cells remain in the vitreous and

SUBMITTER: Norte-Munoz M 

PROVIDER: S-EPMC9392272 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature