Abnormal TNS3 gene methylation in patients with congenital scoliosis.

ABSTRACT:

Background

Congenital scoliosis (CS) is a congenital deformity of the spine resulting from abnormal and asymmetrical development of vertebral bodies during pregnancy. However, the etiology and mechanism of CS remain unclear. Epigenetics is the study of heritable variations in gene expression outside of changes in nucleotide sequence. Among these, DNA methylation was described first and is the most characteristic and most stable epigenetic mechanism. Therefore, in this study, we aim to explore the association between genome methylation and CS which are not been studied before.

Methods

Two pairs of monozygotic twins were included, with each pair involving one individual with and one without CS. Agilent SureSelect XT Human Methyl-Sequencing was used for genome methylation seque

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9392296 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature