Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients.

ABSTRACT:

Background

Less than 20 % of patients with resectable oesophageal adenocarcinoma obtain a pathological response following neoadjuvant chemotherapy. Studies using oesophageal cancer cell lines have shown that drug sensitive tumour cells undergo apoptosis in response to drug treatment, whereas resistant cells induce autophagy and can recover following withdrawal of drug. In this study, we evaluated markers of apoptosis (active/cleaved caspase-3) and autophagy (LC3B) to establish whether these markers are useful prognostic indicators following neoadjuvant therapy.

Methods

Oesophageal adenocarcinoma tumour tissue from the Northern Ireland Biobank at Queens University Belfast was examined retrospectively. Tumours from 144 patients treated with platinum-based neoadjuvant chemother

SUBMITTER: El Mashed S 

PROVIDER: S-EPMC9392302 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature