Lkb1 aggravates diffuse large B-cell lymphoma by promoting the function of Treg cells and immune escape.

ABSTRACT:

Background

Regulatory T cells (Tregs) induce immune responses and may contribute to immune escape in tumors. Accumulation of Tregs in tumors represents a critical barrier to anti-tumor immunity and immunotherapy. However, conflicting results describing the role of Tregs in lymphoma warrant further investigation. The precise features and mechanisms underlying the alteration in Tregs in diffuse large B-cell lymphoma (DLBCL) are not well understood yet. In this study, we analyzed the mechanism underlying the observed alterations in Tregs in DLBCL and examined the effect of Lkb1 expression on the immunosuppressive function of human Tregs.

Methods

Flow cytometry and immunofluorescence were used to analyze the proportion of Tregs and effector Tregs in the peripheral blood and lymp

SUBMITTER: Su X 

PROVIDER: S-EPMC9392310 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature