RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients.

ABSTRACT:

Objective

We aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment.

Methods

After recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis.

Results

SUBMITTER: Xu P 

PROVIDER: S-EPMC9392312 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature