An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae.

ABSTRACT:

Background

Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can provide phenotypic plasticity in reaction to environmental cues. While prior studies suggest that epigenetics plays a role in the response to DNA damage, no direct demonstration of epigenetically inheritable processes have been described in this context.

Results

Here we report the identification of an epigenetic response to ultraviolet (UV) radiation in the baker's yeast Saccharomyces cerevisiae. Cells that have been previously exposed to a low dosage of UV exhibit dramatically increased survival following subsequent UV exposure, which we refer to as UV hyper-resistance (UVHR). This phenotypic change persists for multiple mitotic generations,

SUBMITTER: Reardon RM 

PROVIDER: S-EPMC9392361 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature