Effect of desmopressin on bleeding during endoscopic sinus surgery: A randomized clinical trial.

ABSTRACT:

Background

This study aimed to evaluate the effect of local nasal desmopressin premedication on blood loss and the quality of surgical field in Functional Endoscopic Sinus Surgery (FESS).

Material and methods

In a randomized clinical trial, patients referred for FESS to treat their bilateral chronic rhinosinusitis were recruited. The participants were adults (≥18 years). They were randomly assigned (1:1:1) to receive low-dose (20 μg) or high-dose (40 μg) intranasal desmopressin (DDAVP) or placebo 60 min before the induction of general anesthesia. Standard FESS was performed by the same surgeon. The primary outcomes were volume of intraoperative bleeding and the quality of surgical field. Clean surgical field was defined as a score ≤2 on the Boezaart grading system.

Result

SUBMITTER: Akbarpour M 

PROVIDER: S-EPMC9392372 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature