The protocol for assessing olfactory working memory capacity in mice.

ABSTRACT:

Background

Working memory capacity (WMC) is the ability to maintain information over a few seconds. Although it has been extensively studied in healthy subjects and neuropsychiatric patients, few tasks have been developed to measure such changes in rodents. Many procedures have been used to measure WM in rodents, including the radial arm maze, the WM version of the Morris swimming task, and various delayed matching and nonmatching-to-sample tasks. It should be noted, however, that the memory components assessed in these procedures do not include memory capacity.

Methods

We developed an olfactory working memory capacity (OWMC) paradigm to assess the WMC of 3-month-old 5×FAD mice, a mouse model of Alzheimer's disease. The task is divided into five phases: context adaptation, d

SUBMITTER: Jiang LX 

PROVIDER: S-EPMC9392537 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature