MiR-483-3p improves learning and memory abilities via XPO1 in Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD), a common form of dementia, has been reported to influence 27 million individuals globally. Several risk factors including oxidative stress, gut microbiota imbalance, and cognitive activity are reported to be closely associated with the initiation or progression of AD. Although miR-483-3p was identified to be downregulated in AD patient serum. However, the biological role and mechanism of miR-483-3p remained unknown in AD. Here, we explored the role of miR-483-3p in AD.

Methods

Sprague-Dawley rats were injected with homocysteine (Hcy) to establish an AD animal model. The Morris water maze tests and contextual fear tests were conducted to assess the cognitive and memory abilities of rats. TUNEL staining was utilized to determine cell apop

SUBMITTER: Luo G 

PROVIDER: S-EPMC9392541 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature