UHRF1 Induces Metastasis in Thyroid Cancer.

ABSTRACT:

Background

Ubiquitin-like with PHD and ring-finger domain 1 (UHRF1) has been defined as an oncogene in tumor cells. However, the role of UHRF1 in mediating metastasis in thyroid cancer remains unexplored. In this study, we aimed to investigate the metastatic function and the potential mechanisms of UHRF1 in thyroid cancer.

Methods

Transwell assays were used to detect the metastatic capability of thyroid cancer. Dual-luciferase reporter assays were applied to examine the activation of transcription factors. Coimmunoprecipitation assays and immunofluorescence staining assays were used to elucidate the potential mechanisms of UHRF1 in promoting the metastasis of thyroid cancer.

Results

In this study, we found that overexpression of UHRF1 promoted the metastasis of papill

SUBMITTER: Kuang BH 

PROVIDER: S-EPMC9392644 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature