The Utility of Multistate Models: A Flexible Framework for Time-to-Event Data.

ABSTRACT:

Purpose of review

Survival analyses are common and essential in medical research. Most readers are familiar with Kaplan-Meier curves and Cox models; however, very few are familiar with multistate models. Although multistate models were introduced in 1965, they only recently receive more attention in the medical research community. The current review introduces common terminologies and quantities that can be estimated from multistate models. Examples from published literature are used to illustrate the utility of multistate models.

Recent findings

A figure of states and transitions is a useful depiction of a multistate model. Clinically meaningful quantities that can be estimated from a multistate model include the probability in a state at a given time, the average time in a

SUBMITTER: Le-Rademacher JG 

PROVIDER: S-EPMC9392702 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature