Plant hairy roots for the production of extracellular vesicles with antitumor bioactivity.

ABSTRACT: Plant extracellular vesicles (EVs) concentrate and deliver different types of bioactive molecules in human cells and are excellent candidates for a next-generation drug delivery system. However, the lack of standard protocols for plant EV production and the natural variations of their biomolecular cargo pose serious limitation to their use as therapeutics. To overcome these issues, we set up a versatile and standardized procedure to purify plant EVs from hairy root (HR) cultures, a versatile biotechnological system, already successfully employed as source of bioactive molecules with pharmaceutical and nutraceutical relevance. Herewith, we report that HR of Salvia dominica represent an excellent platform for the production of plant EVs. In particular, EVs derived from S. dominica HRs are sm

SUBMITTER: Boccia E 

PROVIDER: S-EPMC9392725 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature